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Concise synthesis of (+)-fastigiatine

(+)-Fastigiatine was assembled in six steps from (R)-5-methylcyclohex-2-en-1-one. Intermolecular Diels–Alder reaction introduced most of the carbon atoms for the target. The two Boc-protected nitrogen atom building blocks were introduced by a Suzuki coupling and a cuprate addition. A biomimetic tran...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Samame, Renzo A., Owens, Christina M., Rychnovsky, Scott D.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580306/
https://ncbi.nlm.nih.gov/pubmed/28966768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03262h
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