The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells

Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC...

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Pubblicato in:Exp Mol Med
Autori principali: Liu, Chun-Yu, Huang, Tzu-Ting, Chu, Pei-Yi, Huang, Chun-Teng, Lee, Chia-Han, Wang, Wan-Lun, Lau, Ka-Yi, Tsai, Wen-Chun, Chao, Tzu-I, Su, Jung-Chen, Chen, Ming-Huang, Shiau, Chung-Wai, Tseng, Ling-Ming, Chen, Kuen-Feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579508/
https://ncbi.nlm.nih.gov/pubmed/28798401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.114
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