Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progression

BACKGROUND: Triple-negative breast cancer (TNBC) remains difficult to be targeted. SET and cancerous inhibitor of protein phosphatase 2A (CIP2A) are intrinsic protein-interacting inhibitors of protein phosphatase 2A (PP2A) and frequently overexpressed in cancers, whereas reactivating PP2A activity h...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Liu, Chun-Yu, Huang, Tzu-Ting, Chen, Yi-Ting, Chen, Ji-Lin, Chu, Pei-Yi, Huang, Chun-Teng, Wang, Wan-Lun, Lau, Ka-Yi, Dai, Ming-Shen, Shiau, Chung-Wai, Tseng, Ling-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412013/
https://ncbi.nlm.nih.gov/pubmed/30651219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.032
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