Sorafenib analogue SC‐60 induces apoptosis through the SHP‐1/STAT3 pathway and enhances docetaxel cytotoxicity in triple‐negative breast cancer cells

Recurrent triple‐negative breast cancer (TNBC) needs new therapeutic targets. Src homology region 2 domain‐containing phosphatase‐1 (SHP‐1) can act as a tumor suppressor by dephosphorylating oncogenic kinases. One major target of SHP‐1 is STAT3, which is highly activated in TNBC. In this study, we t...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Liu, Chun‐Yu, Su, Jung‐Chen, Huang, Tzu‐Ting, Chu, Pei‐Yi, Huang, Chun‐Teng, Wang, Wan‐Lun, Lee, Chia‐Han, Lau, Ka‐Yi, Tsai, Wen‐Chun, Yang, Hsiu‐Ping, Shiau, Chung‐Wai, Tseng, Ling‐Ming, Chen, Kuen‐Feng
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527447/
https://ncbi.nlm.nih.gov/pubmed/28084011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12033
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