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Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis
Nucleic acids are potent triggers for innate immunity. Double‐stranded DNA and RNA adopt different helical conformations, including the unusual Z‐conformation. Z‐DNA/RNA is recognised by Z‐binding domains (ZBDs), which are present in proteins implicated in antiviral immunity. These include ZBP1 (als...
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| Pubblicato in: | EMBO J |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5579359/ https://ncbi.nlm.nih.gov/pubmed/28716805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201796476 |
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