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Mapping load-bearing in the mammalian spindle reveals local kinetochore-fiber anchorage that provides mechanical isolation and redundancy

Active forces generated at kinetochores move chromosomes, and the dynamic spindle must robustly anchor kinetochore-fibers (k-fibers) to bear this load. The mammalian spindle bears the load of chromosome movement far from poles, but we do not know where and how – physically and molecularly – this loa...

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Publicado en:Curr Biol
Main Authors: Elting, Mary Williard, Prakash, Manu, Udy, Dylan B., Dumont, Sophie
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579025/
https://ncbi.nlm.nih.gov/pubmed/28690110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2017.06.018
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