Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP(+)-dependent isocitrate dehydrogenase (IDH)

DJ-1 is one of the causative genes for early onset familiar Parkinson’s disease (PD) and is also considered to influence the pathogenesis of sporadic PD. DJ-1 has various physiological functions which converge on controlling intracellular reactive oxygen species (ROS) levels. In RNA-sequencing analy...

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Gepubliceerd in:PLoS Genet
Hoofdauteurs: Yang, Jinsung, Kim, Min Ju, Yoon, Woongchang, Kim, Eun Young, Kim, Hyunjin, Lee, Yoonjeong, Min, Boram, Kang, Kyung Shin, Son, Jin H., Park, Hwan Tae, Chung, Jongkyeong, Koh, Hyongjong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578699/
https://ncbi.nlm.nih.gov/pubmed/28827794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006975
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