Silent Information Regulator 2 (Sir2) and Forkhead Box O (FOXO) Complement Mitochondrial Dysfunction and Dopaminergic Neuron Loss in Drosophila PTEN-induced Kinase 1 (PINK1) Null Mutant

PTEN-induced kinase 1 (PINK1), which is associated with early onset Parkinson disease, encodes a serine-threonine kinase that is critical for maintaining mitochondrial function. Moreover, another Parkinson disease-linked gene, parkin, functions downstream of PINK1 in protecting mitochondria and dopa...

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Bibliographische Detailangaben
Hauptverfasser: Koh, Hyongjong, Kim, Hyunjin, Kim, Min Ju, Park, Jeehye, Lee, Hye-Jeong, Chung, Jongkyeong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339960/
https://ncbi.nlm.nih.gov/pubmed/22378780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337907
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