Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria

TRAP1 (tumor necrosis factor receptor-associated protein 1), a mitochondrial Hsp90 family chaperone, has been identified as a critical regulator of cell survival and bioenergetics in tumor cells. To discover novel signaling networks regulated by TRAP1, we generated Drosophila TRAP1 mutants. The muta...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kim, Hyunjin, Yang, Jinsung, Kim, Min Ju, Choi, Sekyu, Chung, Ju-Ryung, Kim, Jong-Min, Yoo, Young Hyun, Chung, Jongkyeong, Koh, Hyongjong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722462/
https://ncbi.nlm.nih.gov/pubmed/26631731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656934
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