Characterization of PINK1 (PTEN-induced Putative Kinase 1) Mutations Associated with Parkinson Disease in Mammalian Cells and Drosophila

Mutations in PINK1 (PTEN-induced putative kinase 1) are tightly linked to autosomal recessive Parkinson disease (PD). Although more than 50 mutations in PINK1 have been discovered, the role of these mutations in PD pathogenesis remains poorly understood. Here, we characterized 17 representative PINK...

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Main Authors: Song, Saera, Jang, Seoyeon, Park, Jeehye, Bang, Sunhoe, Choi, Sekyu, Kwon, Kyum-Yil, Zhuang, Xiaoxi, Kim, Eunjoon, Chung, Jongkyeong
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2013
Ábhair:
Neurobiology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581423/
https://ncbi.nlm.nih.gov/pubmed/23303188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.430801
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