Characterization of PINK1 (PTEN-induced Putative Kinase 1) Mutations Associated with Parkinson Disease in Mammalian Cells and Drosophila

Mutations in PINK1 (PTEN-induced putative kinase 1) are tightly linked to autosomal recessive Parkinson disease (PD). Although more than 50 mutations in PINK1 have been discovered, the role of these mutations in PD pathogenesis remains poorly understood. Here, we characterized 17 representative PINK...

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Detalhes bibliográficos
Main Authors: Song, Saera, Jang, Seoyeon, Park, Jeehye, Bang, Sunhoe, Choi, Sekyu, Kwon, Kyum-Yil, Zhuang, Xiaoxi, Kim, Eunjoon, Chung, Jongkyeong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581423/
https://ncbi.nlm.nih.gov/pubmed/23303188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.430801
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