Role of Phosphoenolpyruvate in the NADP-Isocitrate Dehydrogenase and Isocitrate Lyase Reaction in Escherichia coli

Phosphoenolpyruvate inhibited Escherichia coli NADP-isocitrate dehydrogenase allosterically (K(i) of 0.31 mM) and isocitrate lyase uncompetitively (K(i)′ of 0.893 mM). Phosphoenolpyruvate enhances the uncompetitive inhibition of isocitrate lyase by increasing isocitrate, which protects isocitrate de...

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Bibliographische Detailangaben
Hauptverfasser: Ogawa, Tadashi, Murakami, Keiko, Mori, Hirotada, Ishii, Nobuyoshi, Tomita, Masaru, Yoshin, Masataka
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2007
Schlagworte:
Enzymes and Proteins
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797289/
https://ncbi.nlm.nih.gov/pubmed/17142397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01628-06
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