Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast

Checkpoint signaling requires two conserved phosphatidylinositol 3-kinase-related protein kinases (PIKKs): ATM and ATR. In budding yeast, Tel1 and Mec1 correspond to ATM and ATR, respectively. The Tel2-Tti1-Tti2 (TTT) complex connects to the Rvb1-Rvb2-Tah1-Pih1 (R2TP) complex for the protein stabili...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Goto, Greicy H., Ogi, Hiroo, Biswas, Himadri, Ghosh, Avik, Tanaka, Seiji, Sugimoto, Katsunori
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578694/
https://ncbi.nlm.nih.gov/pubmed/28827813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006873
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