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Asymmetric Synthesis of All-Carbon Quaternary Spirocycles via a Catalytic Enantioselective Allylic Alkylation Strategy

Rapid access to enantioenriched spirocycles possessing a 1,4-dicarbonyl moiety spanning an all-carbon quaternary stereogenic spirocenter was achieved using a masked bromomethyl vinyl ketone reagent. The developed protocol entails an enantioselective palladium-catalyzed allylic alkylation reaction fo...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Tetrahedron Lett
Prif Awduron: Shockley, Samantha E., Hethcox, J. Caleb, Stoltz, Brian M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578629/
https://ncbi.nlm.nih.gov/pubmed/28867835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2017.07.022
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