Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their de...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Ni, Shuaijian, Yao, Houzong, Wang, Lili, Lu, Jun, Jiang, Feng, Lu, Aiping, Zhang, Ge
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2017
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578073/
https://ncbi.nlm.nih.gov/pubmed/28767098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18081683
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