Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase

N-terminal acetylation is an abundant modification influencing protein functions. Since ≈80% of mammalian cytosolic proteins are N-terminally acetylated, this potentially represents an untapped target for chemical control of their functions. Structural studies have revealed that, like lysine acetyla...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Chem Biol
Prif Awduron: Scott, Daniel C., Hammill, Jared T., Min, Jaeki, Rhee, David Y., Connelly, Michele, Sviderskiy, Vladislav O., Bhasin, Deepak, Chen, Yizhe, Ong, Su-Sien, Chai, Sergio C., Goktug, Asli N., Huang, Guochang, Monda, Julie K., Low, Jonathan, Kim, Ho Shin, Paulo, Joao A., Cannon, Joe R., Shelat, Anang A., Chen, Taosheng, Kelsall, Ian R., Alpi, Arno F., Pagala, Vishwajeeth, Wang, Xusheng, Peng, Junmin, Singh, Bhuvanesh, Harper, J. Wade, Schulman, Brenda A., Guy, R. Kip
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577376/
https://ncbi.nlm.nih.gov/pubmed/28581483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2386
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