Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase

N-terminal acetylation is an abundant modification influencing protein functions. Since ≈80% of mammalian cytosolic proteins are N-terminally acetylated, this potentially represents an untapped target for chemical control of their functions. Structural studies have revealed that, like lysine acetyla...

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Publicat a:Nat Chem Biol
Autors principals: Scott, Daniel C., Hammill, Jared T., Min, Jaeki, Rhee, David Y., Connelly, Michele, Sviderskiy, Vladislav O., Bhasin, Deepak, Chen, Yizhe, Ong, Su-Sien, Chai, Sergio C., Goktug, Asli N., Huang, Guochang, Monda, Julie K., Low, Jonathan, Kim, Ho Shin, Paulo, Joao A., Cannon, Joe R., Shelat, Anang A., Chen, Taosheng, Kelsall, Ian R., Alpi, Arno F., Pagala, Vishwajeeth, Wang, Xusheng, Peng, Junmin, Singh, Bhuvanesh, Harper, J. Wade, Schulman, Brenda A., Guy, R. Kip
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577376/
https://ncbi.nlm.nih.gov/pubmed/28581483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2386
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