HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells

Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggressive disease, drug resistance, and poor prognosis. HuR inhibition has profound anticancer activity. Pharmacologic inhibitors can overcome the limitations of genetic inhibition. In this study, we...

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Udgivet i:Sci Rep
Main Authors: Muralidharan, Ranganayaki, Mehta, Meghna, Ahmed, Rebaz, Roy, Sudeshna, Xu, Liang, Aubé, Jeffrey, Chen, Allshine, Zhao, Yan Daniel, Herman, Terence, Ramesh, Rajagopal, Munshi, Anupama
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577245/
https://ncbi.nlm.nih.gov/pubmed/28855578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07787-4
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