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HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression, cell growth, migration, and invasion in lung cancer

The CXCR4 chemokine receptor plays an important role in cancer cell metastasis. The CXCR4 antagonist, AMD3100, has limited efficacy in controlling metastasis. HuR, an RNA-binding protein, regulates CXCR4 in cancer cells. We therefore investigated whether targeting HuR using a siRNA-based nanoparticl...

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Detalhes bibliográficos
Publicado no:Cancer Gene Ther
Main Authors: Muralidharan, Ranganayaki, Panneerselvam, Janani, Chen, Allshine, Zhao, Yan Daniel, Munshi, Anupama, Ramesh, Rajagopal
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679684/
https://ncbi.nlm.nih.gov/pubmed/26494555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2015.55
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