HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression, cell growth, migration, and invasion in lung cancer

The CXCR4 chemokine receptor plays an important role in cancer cell metastasis. The CXCR4 antagonist, AMD3100, has limited efficacy in controlling metastasis. HuR, an RNA-binding protein, regulates CXCR4 in cancer cells. We therefore investigated whether targeting HuR using a siRNA-based nanoparticl...

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Veröffentlicht in:Cancer Gene Ther
Hauptverfasser: Muralidharan, Ranganayaki, Panneerselvam, Janani, Chen, Allshine, Zhao, Yan Daniel, Munshi, Anupama, Ramesh, Rajagopal
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679684/
https://ncbi.nlm.nih.gov/pubmed/26494555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2015.55
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