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HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells

Human antigen (Hu) R is an RNA-binding protein whose overexpression in human cancer correlates with aggressive disease, drug resistance, and poor prognosis. HuR inhibition has profound anticancer activity. Pharmacologic inhibitors can overcome the limitations of genetic inhibition. In this study, we...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Muralidharan, Ranganayaki, Mehta, Meghna, Ahmed, Rebaz, Roy, Sudeshna, Xu, Liang, Aubé, Jeffrey, Chen, Allshine, Zhao, Yan Daniel, Herman, Terence, Ramesh, Rajagopal, Munshi, Anupama
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5577245/
https://ncbi.nlm.nih.gov/pubmed/28855578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07787-4
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