Tumor engraftment in patient-derived xenografts of pancreatic ductal adenocarcinoma is associated with adverse clinicopathological features and poor survival

Patient-derived xenograft (PDX) tumors are powerful tools to study cancer biology. However, the ability of PDX tumors to model the biological and histological diversity of pancreatic ductal adenocarcinoma (PDAC) is not well known. In this study, we subcutaneously implanted 133 primary and metastatic...

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Veröffentlicht in:PLoS One
Hauptverfasser: Pergolini, Ilaria, Morales-Oyarvide, Vicente, Mino-Kenudson, Mari, Honselmann, Kim C., Rosenbaum, Matthew W., Nahar, Sabikun, Kem, Marina, Ferrone, Cristina R., Lillemoe, Keith D., Bardeesy, Nabeel, Ryan, David P., Thayer, Sarah P., Warshaw, Andrew L., Fernández-del Castillo, Carlos, Liss, Andrew S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576681/
https://ncbi.nlm.nih.gov/pubmed/28854237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182855
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