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Elimination or rescue of cells in culture by specifically targeted liposomes containing methotrexate or formyl-tetrahydrofolate.
Methotrexate (Mtx) inhibits cellular proliferation by blocking formyl tetrahydrofolate (THF) production. Mtx- or THF-containing liposomes were covalently coupled to Staphylococcus aureus protein A. These liposomes bound specifically in vitro to cells pre-incubated with relevant monoclonal antibodies...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1984
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC557630/ https://ncbi.nlm.nih.gov/pubmed/6333336 |
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