Elimination or rescue of cells in culture by specifically targeted liposomes containing methotrexate or formyl-tetrahydrofolate.

Methotrexate (Mtx) inhibits cellular proliferation by blocking formyl tetrahydrofolate (THF) production. Mtx- or THF-containing liposomes were covalently coupled to Staphylococcus aureus protein A. These liposomes bound specifically in vitro to cells pre-incubated with relevant monoclonal antibodies...

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Bibliographische Detailangaben
Hauptverfasser: Machy, P, Leserman, L D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1984
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC557630/
https://ncbi.nlm.nih.gov/pubmed/6333336
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