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Antibody-targeted liposomes: increase in specific toxicity of methotrexate-gamma-aspartate.
Liposomes conjugated with anti-H2Kk antibody associate with L929 murine fibroblasts in 6- to 20-fold greater amount than do nonspecific liposomes. The ability of methotrexate-gamma-aspartate to inhibit L929 growth is increased 10-fold when encapsulated in targeted liposomes but is decreased to 50% w...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1983
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393600/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6572395/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.5.1377 |
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