Ontak-like human IL-2 fusion toxin

Ontak(®) is a FDA-approved diphtheria toxin-based recombinant fusion toxin for treatment of human CD25(+) cutaneous T cell lymphoma (CTCL). However, it has been discontinued clinically due to the production issue related to the bacterial expression system with difficult purification. Recently we hav...

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Pubblicato in:J Immunol Methods
Autori principali: Wang, Zhaohui, Zheng, Qian, Zhang, Huiping, Bronson, Roderick T., Madsen, Joren C., Sachs, David H., Huang, Christene A., Wang, Zhirui
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576150/
https://ncbi.nlm.nih.gov/pubmed/28551309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2017.05.008
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