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Synthesis, characterization, in vitro SAR and in vivo evaluation of N,N′bisnaphthylmethyl 2-alkyl substituted imidazolium salts against NSCLC
Alkyl- and N,N′-bisnaphthyl-substituted imidazolium salts were tested in vitro for their anti-cancer activity against four non-small cell lung cancer cell lines (NCI–H460, NCI–H1975, HCC827, A549). All compounds had potent anticancer activity with 2 having IC(50) values in the nanomolar range for th...
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| Pubblicato in: | Bioorg Med Chem Lett |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5575737/ https://ncbi.nlm.nih.gov/pubmed/28126518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.01.035 |
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