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Synthesis, characterization, in vitro SAR study, and preliminary in vivo toxicity evaluation of naphthylmethyl substituted bis-imidazolium salts

A series of novel bis-imidazolium salts was synthesized, characterized, and evaluated in vitro against a panel of non-small cell lung cancer (NSCLC) cells. Two imidazolium cores were connected with alkyl chains of varying lengths to develop a structure activity relationship (SAR). Increasing the len...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Southerland, Marie R., DeBord, Michael A., Johnson, Nicholas A., Crabtree, Steven R., Alexander, Nicolas E., Stromyer, Michael L., Wagers, Patrick O., Panzner, Matthew J., Wesdemiotis, Chrys, Shriver, Leah P., Tessier, Claire A., Youngs, Wiley J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7903221/
https://ncbi.nlm.nih.gov/pubmed/33333447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115893
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