Synthesis, characterization, in vitro SAR study, and preliminary in vivo toxicity evaluation of naphthylmethyl substituted bis-imidazolium salts

A series of novel bis-imidazolium salts was synthesized, characterized, and evaluated in vitro against a panel of non-small cell lung cancer (NSCLC) cells. Two imidazolium cores were connected with alkyl chains of varying lengths to develop a structure activity relationship (SAR). Increasing the len...

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Publicado no:Bioorg Med Chem
Main Authors: Southerland, Marie R., DeBord, Michael A., Johnson, Nicholas A., Crabtree, Steven R., Alexander, Nicolas E., Stromyer, Michael L., Wagers, Patrick O., Panzner, Matthew J., Wesdemiotis, Chrys, Shriver, Leah P., Tessier, Claire A., Youngs, Wiley J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7903221/
https://ncbi.nlm.nih.gov/pubmed/33333447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115893
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