Synthesis, characterization, in vitro SAR and in vivo evaluation of N,N′bisnaphthylmethyl 2-alkyl substituted imidazolium salts against NSCLC

Alkyl- and N,N′-bisnaphthyl-substituted imidazolium salts were tested in vitro for their anti-cancer activity against four non-small cell lung cancer cell lines (NCI–H460, NCI–H1975, HCC827, A549). All compounds had potent anticancer activity with 2 having IC(50) values in the nanomolar range for th...

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Publicado en:Bioorg Med Chem Lett
Main Authors: DeBord, Michael A., Southerland, Marie R., Wagers, Patrick O., Tiemann, Kristin M., Robishaw, Nikki K., Whiddon, Kyle T., Konopka, Michael C., Tessier, Claire A., Shriver, Leah P., Paruchuri, Sailaja, Hunstad, David A., Panzner, Matthew J., Youngs, Wiley J.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575737/
https://ncbi.nlm.nih.gov/pubmed/28126518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.01.035
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