Ordered rearrangement of immunoglobulin heavy chain variable region segments.

The immunoglobulin heavy chain variable region is encoded as three separate libraries of elements in germ-line DNA: VH, D and JH. To examine the order and regulation of their joining, we have developed assays that distinguish their various combinations and have used the assays to study tumor cell an...

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Bibliographic Details
Main Authors: Alt, F W, Yancopoulos, G D, Blackwell, T K, Wood, C, Thomas, E, Boss, M, Coffman, R, Rosenberg, N, Tonegawa, S, Baltimore, D
Format: Artigo
Language:Inglês
Published: 1984
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC557501/
https://ncbi.nlm.nih.gov/pubmed/6086308
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