Aceclofenac nanocrystals with enhanced in vitro, in vivo performance: formulation optimization, characterization, analgesic and acute toxicity studies

This study was aimed to enhance the dissolution rate, oral bioavailability and analgesic potential of the aceclofenac (AC) in the form of nanosuspension using cost-effective simple precipitation–ultrasonication approach. The nanocrystals were produced using the optimum conditions investigated for AC...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Rahim, Haroon, Sadiq, Abdul, Khan, Shahzeb, Khan, Mir Azam, Shah, Syed Muhammad Hassan, Hussain, Zahid, Ullah, Riaz, Shahat, Abdelaaty Abdelaziz, Ibrahim, Khalid
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574597/
https://ncbi.nlm.nih.gov/pubmed/28860715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S140626
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