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Dynactin has two antagonistic regulatory domains and exerts opposing effects on dynein motility

Dynactin is a dynein-regulating protein that increases the processivity of dynein movement on microtubules. Recent studies have shown that a tripartite complex of dynein–dynactin–Bicaudal D2 is essential for highly processive movement. To elucidate the regulation of dynein motility by dynactin, we f...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kobayashi, Takuya, Miyashita, Takuya, Murayama, Takashi, Toyoshima, Yoko Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574551/
https://ncbi.nlm.nih.gov/pubmed/28850609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183672
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