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Break-induced replication links microsatellite expansion to complex genome rearrangements

The instability of microsatellite DNA repeats is responsible for at least forty neurodegenerative diseases. Recently, Mirkin and colleagues presented a novel mechanism for microsatellite expansions based on break-induced replication (BIR) at sites of microsatellite-induced replication stalling and f...

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Detalhes bibliográficos
Publicado no:Bioessays
Autor principal: Leffak, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573876/
https://ncbi.nlm.nih.gov/pubmed/28621832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201700025
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