Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response

The lack of effective chemotherapies for high-grade serous ovarian cancers (HGS-OvCa) has motivated a search for alternative treatment strategies. Here, we present an unbiased systems-approach to interrogate a panel of 14 well-annotated HGS-OvCa patient-derived xenografts for sensitivity to PI3K and...

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Pubblicato in:Nat Commun
Autori principali: Zervantonakis, Ioannis K., Iavarone, Claudia, Chen, Hsing-Yu, Selfors, Laura M., Palakurthi, Sangeetha, Liu, Joyce F., Drapkin, Ronny, Matulonis, Ursula, Leverson, Joel D., Sampath, Deepak, Mills, Gordon B., Brugge, Joan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573720/
https://ncbi.nlm.nih.gov/pubmed/28848242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00263-7
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