Establishment of patient-derived tumor xenograft models of epithelial ovarian cancer for pre-clinical evaluation of novel therapeutics

PURPOSE: Ovarian cancer is the leading cause of death from gynecologic malignancy in the United States, with high rates of recurrence and eventual resistance to cytotoxic chemotherapy. Model systems that allow for accurate and reproducible target discovery and validation are needed to support furthe...

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Pubblicato in:Clin Cancer Res
Autori principali: Liu, Joyce F., Palakurthi, Sangeetha, Zeng, Qing, Zhou, Shan, Ivanova, Elena, Huang, Wei, Zervantonakis, Ioannis K., Selfors, Laura M., Shen, Yiping, Pritchard, Colin C., Zheng, Mei, Adleff, Vilmos, Papp, Eniko, Piao, Huiying, Novak, Marian, Fotheringham, Susan, Wulf, Gerburg M., English, Jessie, Kirschmeier, Paul, Velculescu, Victor, Paweletz, Cloud, Mills, Gordon B., Livingston, David, Brugge, Joan S., Matulonis, Ursula, Drapkin, Ronny
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332350/
https://ncbi.nlm.nih.gov/pubmed/27573169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1237
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