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Applications of Quantum Mechanical/Molecular Mechanical methods to the chemical insertion step of DNA and RNA polymerization
We review theoretical attempts to model the chemical insertion reactions of nucleoside triphosphates catalyzed by the nucleic acid polymerases using combined quantum mechanical/molecular mechanical methodology. Due to an existing excellent database of high resolution x-ray crystal structures, the DN...
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| Veröffentlicht in: | Adv Protein Chem Struct Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5573153/ https://ncbi.nlm.nih.gov/pubmed/25458356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.apcsb.2014.10.001 |
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