Catalytic mechanism of human DNA polymerase λ with Mg(2+) and Mn(2+) from ab initio quantum mechanical/molecular mechanical studies

DNA polymerases play a crucial role in the cell cycle due to their involvement in genome replication and repair. Understanding the reaction mechanism by which these polymerases carry out their function can provide insights into these processes. Recently, the crystal structures of human DNA polymeras...

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Bibliographische Detailangaben
Hauptverfasser: Cisneros, G. Andrés, Perera, Lalith, García-Díaz, Miguel, Bebenek, Katarzyna, Kunkel, Thomas A., Pedersen, Lee G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586819/
https://ncbi.nlm.nih.gov/pubmed/18692600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.07.007
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