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p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine–induced vascular smooth muscle cell migration and proliferation

Although the involvement of Rho proteins in the pathogenesis of vascular diseases is well studied, little is known about the role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs). Here, we sought to identify the RhoGEFs involved in monocyte chemotactic protein 1 (M...

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Publicat a:J Biol Chem
Autors principals: Singh, Nikhlesh K., Janjanam, Jagadeesh, Rao, Gadiparthi N.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572933/
https://ncbi.nlm.nih.gov/pubmed/28655771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.777896
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