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p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine–induced vascular smooth muscle cell migration and proliferation

Although the involvement of Rho proteins in the pathogenesis of vascular diseases is well studied, little is known about the role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs). Here, we sought to identify the RhoGEFs involved in monocyte chemotactic protein 1 (M...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Singh, Nikhlesh K., Janjanam, Jagadeesh, Rao, Gadiparthi N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572933/
https://ncbi.nlm.nih.gov/pubmed/28655771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.777896
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