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Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity
In humans, nonhomologous DNA end-joining (NHEJ) is the major pathway by which DNA double-strand breaks are repaired. Recognition of each broken DNA end by the DNA repair protein Ku is the first step in NHEJ, followed by the iterative binding of nucleases, DNA polymerases, and the XRCC4-DNA ligase IV...
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| Published in: | J Biol Chem |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5572927/ https://ncbi.nlm.nih.gov/pubmed/28696258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.798850 |
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