Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function

There is currently great interest in human serine racemase, the enzyme responsible for producing the NMDA co-agonist d-serine. Reported correlation of d-serine levels with disorders including Alzheimer's disease, ALS, and ischemic brain damage (elevated d-serine) and schizophrenia (reduced d-se...

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Publicado en:J Biol Chem
Autores principales: Nelson, David L., Applegate, Greg A., Beio, Matthew L., Graham, Danielle L., Berkowitz, David B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572919/
https://ncbi.nlm.nih.gov/pubmed/28696262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.777904
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