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The role of the Met(20) loop in the hydride transfer in Escherichia coli dihydrofolate reductase
A key question concerning the catalytic cycle of Escherichia coli dihydrofolate reductase (ecDHFR) is whether the Met(20) loop is dynamically coupled to the chemical step during catalysis. A more basic, yet unanswered question is whether the Met(20) loop adopts a closed conformation during the chemi...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5572915/ https://ncbi.nlm.nih.gov/pubmed/28620051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.777136 |
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