Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice

M2-polarized macrophages, also known as alternatively activated macrophages, have long been associated with pulmonary fibrosis; however, the mechanism has not been fully defined. Gab1 and Gab2 proteins belong to the Gab family of adaptors and are integral components of the signal specificity in resp...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Guo, Xiaohong, Li, Tingting, Xu, Yun, Xu, Xiayan, Zhu, Zhengyi, Zhang, Yun, Xu, Jiaqi, Xu, Kaihong, Cheng, Hongqiang, Zhang, Xue, Ke, Yuehai
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572909/
https://ncbi.nlm.nih.gov/pubmed/28687632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.802066
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items