Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice

M2-polarized macrophages, also known as alternatively activated macrophages, have long been associated with pulmonary fibrosis; however, the mechanism has not been fully defined. Gab1 and Gab2 proteins belong to the Gab family of adaptors and are integral components of the signal specificity in resp...

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Udgivet i:J Biol Chem
Main Authors: Guo, Xiaohong, Li, Tingting, Xu, Yun, Xu, Xiayan, Zhu, Zhengyi, Zhang, Yun, Xu, Jiaqi, Xu, Kaihong, Cheng, Hongqiang, Zhang, Xue, Ke, Yuehai
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572909/
https://ncbi.nlm.nih.gov/pubmed/28687632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.802066
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