Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice

M2-polarized macrophages, also known as alternatively activated macrophages, have long been associated with pulmonary fibrosis; however, the mechanism has not been fully defined. Gab1 and Gab2 proteins belong to the Gab family of adaptors and are integral components of the signal specificity in resp...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Guo, Xiaohong, Li, Tingting, Xu, Yun, Xu, Xiayan, Zhu, Zhengyi, Zhang, Yun, Xu, Jiaqi, Xu, Kaihong, Cheng, Hongqiang, Zhang, Xue, Ke, Yuehai
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572909/
https://ncbi.nlm.nih.gov/pubmed/28687632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.802066
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares