Profibrotic Effect of Interleukin-18 in HK-2 Cells Is Dependent on Stimulation of the Toll-like Receptor 4 (TLR4) Promoter and Increased TLR4 Expression

IL-18 is an important mediator of obstruction-induced renal fibrosis and tubular epithelial cell injury independent of TGF-β1 activity. We sought to determine whether the profibrotic effect of IL-18 is mediated through Toll-like receptor 4 (TLR4). Male C57BL6 wild type and mice transgenic for human...

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Autores principales: Meldrum, Kirstan K., Zhang, Hongji, Hile, Karen L., Moldower, Lyle L., Dong, Zizheng, Meldrum, Daniel R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504754/
https://ncbi.nlm.nih.gov/pubmed/23027874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402420
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