IL-18 Activation is Dependent on Toll Like Receptor 4 during Renal Obstruction

PURPOSE: Interleukin-18 (IL-18) is a critical mediator of obstruction-induced renal injury. While previous studies have demonstrated that IL-18 participates in a positive feedback loop via the IL-18 receptor (IL-18R) and localized renal IL-18 and IL-18R production to tubular epithelial cells (TEC),...

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Main Authors: Rhee, Audrey C., Cain, Alexandra L., Hile, Karen L., Zhang, Hongji, Matsui, Futoshi, Meldrum, Kirstan K.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959649/
https://ncbi.nlm.nih.gov/pubmed/23260234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2012.11.038
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