IL-18 STIMULATES A POSITIVE FEEDBACK LOOP DURING RENAL OBSTRUCTION VIA THE IL-18 RECEPTOR

BACKGROUND: IL-18 is a pro-inflammatory cytokine that has recently been demonstrated to be an important mediator of obstruction-induced renal tubulointerstitial fibrosis independent of TNF-α and TGF-β1 activity. We hypothesized that IL-18 stimulates a positive feedback loop during obstruction via th...

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Udgivet i:J Urol
Main Authors: VanderBrink, Brian A., Asanuma, Hiroshi, Hile, Karen, Zhang, Honji, Rink, Richard C., Meldrum, Kirstan K.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520633/
https://ncbi.nlm.nih.gov/pubmed/21855933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2011.05.046
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