β-Arrestin 2 Negatively Regulates Toll-like Receptor 4 (TLR4)-triggered Inflammatory Signaling via Targeting p38 MAPK and Interleukin 10

The control of IL-10 production in Toll-like receptor (TLR) signals remains to be elucidated. Here, we report that β-arrestin 2 positively regulates TLR-triggered IL-10 production in a p38 mitogen-activated protein kinase (MAPK)-dependent mechanism. In vitro studies with cells including peritoneal m...

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Detalhes bibliográficos
Main Authors: Li, Hui, Hu, Dan, Fan, Huimin, Zhang, Ying, LeSage, Gene D., Caudle, Yi, Stuart, Charles, Liu, Zhongmin, Yin, Deling
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132806/
https://ncbi.nlm.nih.gov/pubmed/25012660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.591495
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