Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response

Nonalcoholic fatty liver disease (steatosis) is the most prevalent liver disease in the Western world. One of the advanced pathologies is nonalcoholic steatohepatitis (NASH), which is associated with induction of the unfolded protein response (UPR) and disruption of autophagic flux. However, the mec...

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Pubblicato in:J Biol Chem
Autori principali: Willy, Jeffrey A., Young, Sara K., Mosley, Amber L., Gawrieh, Samer, Stevens, James L., Masuoka, Howard C., Wek, Ronald C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Protein Synthesis and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572902/
https://ncbi.nlm.nih.gov/pubmed/28710282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.799304
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