Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk

Bruton's tyrosine kinase (Btk) is required for B-cell development. Btk deficiency causes X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (Xid) in mice. Btk lacks a negative regulatory domain and may rely on cytoplasmic proteins to regulate its activity. Consistently, w...

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Detalhes bibliográficos
Main Authors: Spatuzza, Carmen, Schiavone, Marco, Di Salle, Emanuela, Janda, Elzbieta, Sardiello, Marco, Fiume, Giuseppe, Fierro, Olga, Simonetta, Marco, Argiriou, Notis, Faraonio, Raffaella, Capparelli, Rosanna, Quinto, Ileana, Scala, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490745/
https://ncbi.nlm.nih.gov/pubmed/18596081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn413
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